- Deuterium-depleted water was found to stimulate GLUT4 translocation in the presence of insulin, leading to decreased blood glucose concentration. The study tested the effect of subnormal deuterium concentration on glucose metabolism in streptozotocin-induced diabetic rats.
- The results showed that in the presence of insulin, deuterium depletion markedly reduced serum glucose, fructosamine and HbA1c levels in a dose-dependent manner. The optimal deuterium concentration was between 125 and 140 ppm.
- After 4 weeks, the highest membrane-associated GLUT4 content was detected at 125 ppm. This suggests that deuterium depletion potentiates the effect of insulin on GLUT4 translocation and glucose uptake in diabetic rats, explaining the lower serum glucose levels.
- Based on the results, deuterium-depleted water could be used to treat patients with metabolic syndrome by increasing insulin sensitivity.
“Deuterium-depleted water enhances insulin’s effect, significantly reducing glucose levels in diabetic rats. This increase in insulin sensitivity is linked to the stimulation of GLUT4 translocation. Optimal effects were observed at 125-140 parts per million deuterium concentration, suggesting potential for diabetes treatment.”
Study by
Miklós Molnár
· Katalin Horváth
· Tamás Dankó
· Ildikó Somlyai
· Beáta Zs. Kovács
· Gábor Somlyai
What effect did deuterium-depleted water have on glucose metabolism in diabetic rats?
The study found that deuterium-depleted water had a significant effect on glucose metabolism in diabetic rats. It was observed that when the rats were given deuterium-depleted water, it stimulated GLUT4 translocation in the presence of insulin. This in turn led to a decreased blood glucose concentration.
In the streptozotocin-induced diabetic rat model, the effects of deuterium-depleted water were tested on glucose metabolism in diabetic animals with or without insulin treatment. The results showed a marked reduction in serum glucose, fructosamine, and HbA1c levels in a dose-dependent manner.
It’s also important to note that while there was an initial hypothesis that deuterium depletion could stabilize insulin in the plasma, leading to lower blood glucose levels, the data did not support this. The insulin concentration remained the highest two hours after administration and there was a gradual decrease for 10 hours until the next administration, regardless of the concentration of deuterium in the drinking water.
So, in summary, deuterium-depleted water appears to enhance the effect of insulin on GLUT4 translocation and glucose uptake in diabetic rats, leading to lower serum glucose levels.
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How did deuterium depletion enhance the effect of insulin?
According to the study, the exact mechanism by which deuterium depletion enhances the effect of insulin is not clearly understood yet. However, the study suggests that it has something to do with the effect of deuterium depletion on GLUT4 translocation. GLUT4 is a protein that plays a crucial role in insulin-regulated glucose transport into cells.
In the presence of insulin, deuterium depletion was found to markedly increase the amount of GLUT4 present on the cell surface (membrane-associated GLUT4), which in turn increases the cell’s uptake of glucose. This effect was observed to be dose-dependent, with the highest membrane-associated GLUT4 content detected at a deuterium concentration of 125 ppm.
The study also suggested that the observed effects cannot be attributed solely to the kinetic isotope effect, implying that other complex cellular mechanisms may be at play. For instance, a change in the D/H ratio due to deuterium depletion might affect submolecular regulatory systems or the functioning of mitochondria, impacting metabolic processes and insulin sensitivity.
However, more research is needed to fully understand the underlying mechanisms by which deuterium depletion affects insulin action and glucose metabolism.
What was the optimal deuterium concentration found in the study?
The study found that the optimal deuterium concentration was in the range of 125-140 parts per million (ppm). Within this range, the effects of deuterium depletion on enhancing insulin sensitivity and reducing blood glucose levels were most pronounced. For instance, the highest membrane-associated GLUT4 content, which correlates with increased glucose uptake by cells, was detected at a deuterium concentration of 125 ppm. Moreover, animals that received drinking water with deuterium concentration below 140 ppm showed significantly lower blood glucose, fructosamine, and HbA1c levels compared to those that had access to tap water.
Therefore, this range of deuterium concentration (125-140 ppm) seems to be the most effective for the observed effects.
Source : Deuterium‑depleted water stimulates GLUT4 translocation in the presence of insulin, which leads to decreased blood glucose concentration by
Link : https://link.springer.com/article/10.1007/s11010-021-04231-0